MALDI Mass Spectrometry of Small Molecules Using Nanometer-sized Clay

Identi cation of Small Molecules using Mass Spectrometry

Metabolites, small molecules that are produced by an organism, possess a broad range of functions from energy provision to the transfer of complex messages. A large number of metabolites still remain unknown. As metabolites often directly in uence the phenotype, the biology of an organism can not be fully understood without uncovering most of its metabolites. Additionally, a newly found metabol...

Advances in structure elucidation of small molecules using mass spectrometry

The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as ...

Mass Spectrometry of Biologically Active Small Molecules

The main foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols, alkaloids and amino acids published in five appended studies are presented and discussed. Various MS methods were applie...

Using AP-MALDI Ion Trap Mass Spectrometry

Computational mass spectrometry for small molecules

: The identification of small molecules from mass spectrometry (MS) data remains a major challenge in the interpretation of MS data. This review covers the computational aspects of identifying small molecules, from the identification of a compound searching a reference spectral library, to the structural elucidation of unknowns. In detail, we describe the basic principles and pitfalls of search...